Calcium and Magnesium Don't Mix, Along With These 6 Other Supplement Combinations

Almost 75 percent of Americans take dietary supplements, with more than half doing so on a regular basis. While these supplements can benefit people with deficiencies, certain combinations can cause health problems. 

While some supplements work better when taken simultaneously, creating a synergistic effect — others should not be combined. Whether because of absorption issues or possible harm, it’s best to wait at least two hours between certain supplements for safety reasons.

Magnesium has a multitude of health benefits, including relieving constipation and having a positive effect on heart health. Calcium is needed for bone growth and maintenance, and also plays a role in blood clotting, muscle contraction and relaxation. 

Taken together, they both become less effective since they compete for absorption. However, spacing them apart by taking calcium with a meal and taking magnesium at night is a way to ensure the supplements don’t interact.

Iron plays a role in hemoglobin production, immune system support, pregnancy health, increased energy, and improved athletic performance. And green tea is high in antioxidants and offers health benefits that include reduction of inflammation, protection from oxidative stress, and the potential to lower blood sugar and reduce cancer risk.

Because green tea inhibits iron absorption, it's best not to take iron and green tea simultaneously, whether as a supplement or a drink. 

Read More: What You Should Know About Magnesium Supplements

Although vitamin C is best known for supporting the immune system, it also helps to heal wounds and repair bones. While it works in conjunction with other supplements, such as iron and zinc — the opposite is true with vitamin B12. 

High doses of vitamin C actually impedes the absorption of B12. Since B12 is needed for red blood cell formation, nerve function, cell metabolism, and the repair of body tissues, you don’t want to diminish the maximum potential benefit by diminishing its effectiveness. 

Omega-3-rich fish oil supplements are touted for reducing triglyceride levels, blood pressure, and inflammation. It’s also believed they may protect skin and eye health.

Ginkgo biloba is used to treat cognitive impairment, to reduce symptoms of dementia and Alzheimer’s disease, as well as help alleviate depression and anxiety. Together, fish oil and Ginkgo biloba both have blood-thinning properties and can increase the risk of bleeding or prevent blood clotting.

Read More: What You Need to Know About Vitamin C, Vitamin B, Turmeric, and Fish Oil/Omega-3

Copper is key in the formation of red blood cells, bone, and connective tissue — while zinc plays a central role in immune function, wound healing, and sense of smell and taste.

Many people don’t realize that when taken in large amounts, zinc can deplete the copper in our bodies — creating a need for copper supplements. Since they’re both absorbed by the small intestine, they should be spaced out so as to not compete for absorption.  

Vitamin E has antioxidant properties that help control free radicals, which are related to oxidative stress. But vitamin E can also have a blood-thinning effect, impeding the body’s ability to clot properly.

Conversely, vitamin K increases blood clotting properties — in particular, the protein prothrombin. Because vitamin E can counteract the clotting effect of vitamin K, it can lead to coagulation issues and bleeding. 

While maintaining a sufficient amount of copper is important for optimal health — it can be difficult to find just the right level. Too much can cause negative effects, and too little could lead to problems with bone strength, iron transport, glucose metabolism, and more.

Vitamin C is also essential for good health. But when taken together, they can result in the Fenton reaction, which leads to highly reactive hydroxyl radicals. These can cause kidney damage.

Before taking certain supplements, it's always best to consult a healthcare professional first.

Read More: Here’s Why You May Want To Take Vitamin D and Magnesium Together

Our writers at Discovermagazine.com use peer-reviewed studies and high quality sources for our articles and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:

• The Council for Responsible Nutrition. Three-quarters of Americans Take Dietary Supplements; Most Users Agree They are Essential to Maintaining Health, CRN Consumer Survey Finds

• Power Ultrasonics. Synergistic Effect

• Clinical Case Reports. Iron deficiency anemia due to excessive green tea drinking

• National Institutes of Health. Vitamin C. Fact Sheet for Professionals

• National Institutes of Health. Vitamin B12. Fact Sheet for Consumers

• StatPearls. Ginkgo Biloba

• National Institutes of Health. Copper. Fact Sheet for Health Professionals

• Free radical biology & medicine. Vitamin E and oxidative stress

• Biomolecules. The Combined Administration of Vitamin C and Copper Induces a Systemic Oxidative Stress and Kidney Injury