Linking Inflammation to Depression Could Yield More Targeted Treatment

Animal studies could lead to blood tests that could guide doctors in better matching drugs to patients based on immune system biomarkers.

By Paul Smaglik
Apr 2, 2025 1:00 PM
Immune system cells
(Image Credit: PeopleImages.com - Yuri A/Shutterstock)

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Prozac’s approval by the U.S. Food and Drug Administration (FDA) in 1988 heralded the dawn of a new age in treating depression since it focused on serotonin, a brain chemical that, when in short supply, contributes to depression. It was more targeted and had fewer and generally less harsh side effects than the classic treatments— tricyclics and monoamine oxidase inhibitors (MAOIs).

Since then, a total of seven selective serotonin reuptake inhibitors (SSRIs) that essentially help the neurotransmitter serotonin build up in the brain by blocking its escape, have hit the market, as have several serotonin and norepinephrine reuptake inhibitors (SNRIs), which target serotonin and another neurotransmitter associated with the disorder. They are joined by drugs such as Wellbutrin, which don’t fit into specific chemical categories.

Some cases of depression don't respond to medication, however. Scientists have hypothesized that inflammation — which seems to play a role in many aspects of our health, including our immune system and our metabolism — may also contribute to depression as well as the condition’s response to treatment. Now, scientists in Australia have conducted work in rats that connect how inflammation can disrupt metabolism, thus making depression treatment more challenging, they report in the journal Brain, Behavior, and Immunity. If replicated in humans, the research could help better match medications to patients.

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