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Studying Ancient Viruses Could Save Humans From Modern Diseases

A surge of research into ancient killers may help us outsmart them in the future.

Key developments allowed the current flood of research into ancient pathogens: Powerful new data-crunching software and many more ancient genomes available for study, such as from these 4,500-year-old skeletons in Mongolia which contained the hepatitis B virus.Credit: Alexey A. Kovalev

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The deadliest and most devastating opponents our species has faced have never been across a battlefield. They’ve been on our skin and in our blood and bones.

Viruses and bacteria have killed or debilitated millions during the course of human history — and well before. Researchers have unraveled the story of a few, most notably the bacterium Yersinia pestis, which causes plague. But findings about the origins and evolution of other scourges, including leprosy, hepatitis B and syphilis, have been elusive or contradictory.

Now, two key advances — a surge in ancient DNA samples and powerful computer programs to process the data — are allowing scientists to study disease-causing bacteria and viruses like never before.

“There were very few ancient human virus samples even six months ago,” says Terry Jones, a computational biologist at the University of Cambridge. “In terms of being ‘ancient,’ 300 years was considered old, and that ...

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