The Discovery of TDP 43 Dementia and How It Strikes the Oldest Ages

TDP 43 Dementia is a neurological disorder characterized by the abnormal accumulation of protein in the brain. Learn how it was discovered.

By Linda Marsa
Dec 23, 2019 10:00 PMAug 10, 2023 2:04 PM
Dementia Neuropathologist, Peter-Nelson
Neuropathologist Peter Nelson analyzed dementia patients’ brains postmortem. (Credit: Mark Cornelison)

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So many older people experience the tell-tale symptoms of Alzheimer’s disease, like forgetfulness and muddled thinking. Yet post-mortem autopsies often find none of the amyloid plaques or tau tangles that are hallmarks of the mind-robbing illness.

Now, scientists may have solved this perplexing mystery: These patients are probably affected by a newly identified degenerative disorder that mimics Alzheimer’s and could be just as prevalent among older adults.

LATE Dementia

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