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NCBI ROFL: Asparagus, urine, farts, and Benjamin Franklin (Part I)

Discover why asparagus creates a malodorous urine smell due to specific sulfur compounds. Learn about smell hypersensitivity too!

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A polymorphism of the ability to smell urinary metabolites of asparagus.

"The urinary excretion of (an) odorous substance(s) after eating asparagus is not an inborn error of metabolism as has been supposed. The detection of the odour constitutes a specific smell hypersensitivity. Those who could smell the odour in their own urine could all smell it in the urine of anyone who had eaten asparagus, whether or not that person was able to smell it himself. Thresholds for detecting the odour appeared to be bimodal in distribution, with 10% of 307 subjects tested able to smell it at high dilutions, suggesting a genetically determined specific hypersensitivity."

Face it: your pee smells after you eat asparagus. (And if you think yours doesn't, it's because you can't smell it.) This phenomenon (which is caused by various malodorous sulfur-containing compounds) has tickled the fancies of many researchers, as well as such luminaries as ...

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