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Beyond Psilocybin: Mushrooms Have Lots of Cool Compounds Scientists Should Study

There's way more out there than just "magic" mushrooms.

The Crux
By Troy Farah
Oct 16, 2018 10:12 PMMay 19, 2020 2:24 AM
amanita muscaria
Amanita muscaria. (Credit: FotoLot/Shutterstock)

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Psilocybin mushrooms, the “magic” fungi famous for giving users hallucinations and spiritual insight, may not actually be supernatural, but they come pretty close. A growing body of research suggests they might help treat a range of mental disorders, and there’s little evidence that they’re addictive.

But the world of magic mushrooms extends far beyond psilocybin. Though they may not have intended it, these fungal chemical factories are synthesizing chemicals that just so happen to carry beneficial properties for humans, as well.

Mushroom 101

From Agaricus bisporus (portobello) to Amanita phalloides, the aptly-named, very lethal death cap toadstool, mushrooms come in all manner of sizes, colors, and flavors. They’re part of the fungi kingdom, along with molds and yeasts. Some are microscopic; another can be considered the largest living organism on Earth. With only around 100,000 species described, out of an estimated 5.1 million, fungi make ideal candidates for bioprospecting, or extracting useful compounds for pharmaceuticals and other things from nature.

Mushrooms are actually just the above-ground portion of certain fungi. Some species grow a root-like system called a mycelium, which sprout into mushrooms when they reach the surface. They sprinkle spores, the fungal equivalent of a seed, so the cycle can begin again. It sounds suspiciously plant-like, but mushrooms are actually closer genetically to animals than to plants.

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