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How to Build Aliens in the Lab

To find life on Earth, follow the water. But what about on other planets?

By Kiona N. Smith
Jun 26, 2019 5:00 PMAug 29, 2023 2:17 PM
DSC-LA0719 01 oil droplets
(Credit: Derivative of “Oil Abstract, Alternate” by Tim Sackton)

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Earth is teeming with life — and water makes it all possible. But elsewhere in the cosmos, life might be built from different chemicals that dissolve and assemble in some other liquid: perhaps methane, kerosene, or even chloroform. For now, it’s not feasible for humans to set foot on those worlds and see what’s there, but researchers are exploring some possibilities in labs here on Earth. 

The idea of a strange parallel form of life, whose cells do the same basic things as ours using a completely different chemistry, isn’t new to science. Isaac Asimov first broached the subject in his 1962 essay “Not as We Know It: The Chemistry of Life.” And in 2004, the same year the Cassini spacecraft entered Saturn’s orbit, biochemist Steven Benner proposed in a paper in Current Opinion in Biological Chemistry that on a world like Saturn’s moon Titan, life might use liquid hydrocarbons as a solvent (a liquid that can dissolve other substances), the way water is used on Earth.

With new exoplanets joining the roster of known worlds every day, it’s likely that some of them have oceans (or at least warm puddles) of hexane, ethers, chloroform, or other exotic liquids that might serve as the basis for life as we don’t yet know it. 

Gathering the Pieces

In such alien oceans, the chemistry of life on Earth just wouldn’t work. Water is a polar molecule; its oxygen end has a slight negative charge, while its hydrogen end has a slight positive charge. Those charges affect the kinds of chemical bonds that can happen in water. The structure of molecules like DNA and proteins depends on water’s polar hydrogen bonds.

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