As Milinkovitch scrutinized differences between embryos of his naked dragons and normal lizards, he realized normal lizards do have placodes, but they exist for a few hours and appear in different places depending on the species and the developmental stage.
“You have to look really at the right time, at the right place, otherwise you just miss them,” Milinkovitch says. Knowing where and when to look, he found placodes in other reptiles, too.
He also discovered why his dragons were naked: A mutated gene involved in placode formation. Other vertebrates — including humans — share this gene. When mutations occur there, the vertebrates may end up with missing placodes, or sweat glands, teeth or nails that are deformed or just absent.
Milinkovitch and co-author Nicolas Di-Poï published these findings in June in Science Advances, finally closing the book on this long-standing mystery.