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Drug Couriers for Brain Injuries

A small protein could lead to a cure for traumatic brain injuries.

By Teal Burrell|Wednesday, December 21, 2016
drug-courier
drug-courier
In a mouse brain, the CAQK peptide binds to injured sites more effectively than the control. (Cooler colors signal lower peptide levels; warmer colors signal higher levels.)
Reprinted by permission from MacMillan Publishers Ltd: Aman P. Mann et al./Nature Communications/10.1038/ncomms11980/28 June 2016

A short protein fragment, or peptide, may lead the way to healing traumatic brain injuries, a primary cause of death and disability among youth.

Currently, drugs to treat such injuries are injected directly into the brain — an invasive technique — or into the bloodstream, which allows the medication to spread throughout the brain, causing harmful side effects. Attaching drugs to the new peptide, called CAQK, would avoid these problems. The peptide, just four amino acids long, binds to a protein complex that’s more abundant in injured areas and can therefore carry the therapy through the blood straight to the damaged sites.

CAQK
CAQK
The 1-in-a-billion CAQK peptide (dark blue) also targets injured sites in human brain samples, showing its potential for precise drug delivery.
Reprinted by permission from MacMillan Publishers Ltd: Aman P. Mann et al./Nature Communications/10.1038/ncomms11980/28 June 2016
To find the chemical courier, a team led by Erkki Ruoslahti of Sanford Burnham Prebys Medical Discovery Institute in California tested 1 billion random combinations of amino acids — just one robustly bound specifically to injured brain tissue of mice and humans. The results were published in Nature Communications in June.

“We get more of the drug to go to the injury and to stay there,” Ruoslahti says. Now, older treatments that were abandoned because they didn’t latch to injured areas or had negative side effects could be revived.

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