Engineer Aydogan Ozcan and his team created their mobile microscopy unit by souping up the camera of a Nokia Lumia 1020 smartphone. They attached an external lens, filters, focuser and laser, adding less than 7 ounces. After placing a DNA sample on a glass coverslip, the researchers use the laser to excite the DNA molecules and make them visible. The smartphone’s camera then snaps a picture of the coverslip through its lenses and filters. Finally, the image is sent to a UCLA server for digital processing.
Ozcan and his colleagues demonstrated that their $400 setup could identify copy-number variations and, subsequently, disease risk, replacing detection methods that require hundreds of thousands of dollars of equipment. Medical staff practicing in rural or resource-limited environments would benefit the most from this immediate and low-cost risk assessment, Ozcan suggests.
[This article originally appeared in print as "A Lab in Your Pocket."]