#97

Cells Battle to the Death in the Developing Embryo

Survival of the fittest appears to govern the earliest days of an embryo's development.

By Jeff Wheelwright|Wednesday, January 29, 2014
RELATED TAGS: SEX & REPRODUCTION
mouse-embryo
mouse-embryo
An 11-day-old mouse embryo.
Natalia Sinjushina & Evgeniy Meyke / Shutterstock

Charles Darwin established the idea of competition between organisms to ensure the survival of the fittest. In July, researchers in Spain reported the same competition happening within an organism. During the early days of a mouse embryo’s development, cells with higher levels of a protein called Myc outdo cells expressing lower amounts of Myc. All the cells are healthy, emphasizes first author Cristina Clavería of the Centro Nacional de Investigaciones Cardiovasculares in Madrid. But after the cells come in contact, the “losers” die, donating their biochemical innards to their presumably fitter counterparts. “There’s communication between winners and losers, but which way the signal goes, we’re not sure,” she says. The contest ends after a week; at that time, Clavería predicts, surviving cells produce uniform (and higher) levels of Myc.

Myc is an important player in the growth of organisms and also is implicated in cancer, another unhealthy competition between cells. Perhaps, Clavería says, cell expansion driven by Myc sets the stage for a tumor.

[This article originally appeared in print as "Cell Battle to the Death."]

Comment on this article
ADVERTISEMENT

Discover's Newsletter

Sign up to get the latest science news delivered weekly right to your inbox!

ADVERTISEMENT
ADVERTISEMENT
Collapse bottom bar
DSCJulyAugCover
+

Log in to your account

X
Email address:
Password:
Remember me
Forgot your password?
No problem. Click here to have it emailed to you.

Not registered yet?

Register now for FREE. It takes only a few seconds to complete. Register now »