3. Synthetic Molecules
Researchers at Northwestern University recently engineered versions of antimicrobial peptides to make them more resilient. Called peptoids, these synthetic molecules are stronger than natural peptides, last longer in the body, and are cheaper to produce. When the scientists added them to cultures of six bacteria known to cause food poisoning, pneumonia, hospital-acquired infections, and ear and heart infections, the peptoids wiped them all out.
4. Focused phages
If bacteria evolve to become drug resistant, why not subject them to bacteria-fighting microbes, called phages, that evolve along with them? When ingested or topically applied, phages cure infections but leave the rest of the body and “good” bacteria alone. So-called phage therapy is widely used in Eastern Europe and is currently undergoing one U.S. clinical trial. Since phages have evolved with their bacterial targets for billions of years, they could solve the problem of antibiotic resistance for good; the downside is that each bacterial strain requires its own tailored phage cocktail, so it could be many years before doctors have a suitably broad range of phages at their disposal.
5. Cholesterol Drugs
MRSA bacteria produce an antioxidant that helps destroy toxic free radicals generated in the infection-fighting process. The antioxidant, scientists found, is produced through a process similar to one used by humans to manufacture cholesterol. Thus, researchers wonder whether cholesterol-lowering compounds might act as a new sort of antibiotic. Mice given the drug and then infected with MRSA had 98 percent less bacteria than mice not given the drug.
