Speaking of hype, Suzanne Somers has been prominently pushing bioidentical hormones as a way of slowing the aging process, replacing the hormones that dropoff as we age with natural compounds that are structurally identical.Mainstream researchers are dubious about this approach. Why?
Dunaif You’ve got two issues here. One, if we replace those hormones, does that help? And two, although we don’t have the data with the bioidentical hormones, we know from the Women’s Health Initiative that estrogens were not the fountain of youth that Suzanne Somers sort of claims. They didn’t keep you sharper and heart-attack free. And then you get into this sham argument that because this hormone is not the hormone that was used in the study, because it’s identical to what the body makes, it doesn’t have the side effects. Scientific data do not support that. In fact, what pharmaceutical companies make, because it’s a highly regulated industry, is much safer and much purer than bioidentical hormones.
Somers argues that the reason that we don’t have good data on bioidentical hormones is that they can’t be patented so there’s no industry money behind them. Why aren’t the pharma companies investigating these compounds?
Constantine Why would I test somebody else’s product for safety and efficacy? To say, “They haven’t tested my product” is, quite honestly, a ridiculous argument. I would think the person who’s making the profit has the responsibility for testing, and it’s certainly not the pharmaceutical company; it is the people making the bioidenticals, the people who are selling the books, the people who are on the speaking tours. They’re making a profit off that, I would imagine, and it would behoove them to study it.
Dunaif I think we’ve got a little confusion here, because what Suzanne Somers is talking about—bioidentical estrogen—is the same product that is marketed by a number of pharmaceutical companies. There are studies that are not as big as the Women’s Health Initiative showing that it is equivalent in outcome parameters to Premarin [a pharmaceutical estrogen]. There are no data showing that these different preparations of estrogen differ biologically. The reason bioidentical hormones aren’t getting tested—it is for reasons that I think are just outrageous to the public. The FDA doesn’t regulate this industry, so somebody in a compounding pharmacy is literally making hooch. You don’t know what concentration you’re getting. You don’t know what your blood levels are. And you’ve got somebody selling the idea that because of a great conspiracy, bioidenticals are safer than what the pharmaceutical companies are selling—and that is totally wrong.
Dobs I think the public is sometimes quite naive about the complexity of doing research. First, it is extremely expensive. The Women’s Health Initiative or a comparable study using testosterone in men costs billions of dollars and many years. To do a study like that takes a lot of time, a lot of money, a lot of people willing to volunteer to participate in research like that.
Dunaif Right now we have great examples of the challenges involved. We have Vioxx being pulled off the market. We’ve got rosiglitazone [Avandia] being questioned. On one hand, you’ve got all the newspapers and Congress saying: “You didn’t test it enough. You didn’t do it in 5,000 people to find out there’s a bad effect.” On the other hand, you have people saying: “You’re keeping something from us. This is a conspiracy.”
Which gets back to the idea that people are looking for a miracle pill. Why this obsession with youth? People have been growing old forever—why is fulfilling our biological destiny now considered a disease?
Dunaif The sociological experience of women has dramatically changed in this century, much more so than any century prior, and our biology has not caught up with our social circumstances. We have a number of women who are coming into their careers only in their thirties and forties. We have pushed the envelope in terms of reproductive possibilities into perimenopausal pregnancies, even postmenopausal pregnancies, so there’s tremendous dissatisfaction with an aging body at a very young sociological age—it’s a huge contrast.
Thorner I think the real public-health issue that we’re going to be dealing with is a large number of people in this country who are going to be frail and elderly. In a society where the proportion of the old population is getting larger and larger, it’s not going to be economically possible for all these people to be looked after. It’s a serious issue.
So how far can antiaging therapy take us? Can it address these social and psychological issues in addition to the obvious biological goals of staying vigorous into old age?
Rosenthal Ultimately, we might do a very good job of preserving ourselves physiologically, but there are tremendous problems that people still suffer from in terms of psychological issues and spiritual issues—the absence of a rich life in the parts that you can’t see. In addition, we’re very far away in research from really understanding the aging brain, fixing Alzheimer’s disease, stopping all kinds of dementia-related diseases. We may wind up with large numbers of people who may not have quality of mind even though they have quality of body, and that’s just going to create more problems and more questions.
Dunaif And even though we may have therapies to prevent aging in the future, there are going to be tremendous disparities in who has access to those therapies. We may wind up in a societal dilemma where wrinkles will be a sign of poverty, and lovely-looking skin and great libidos will be a sign of wealth.
Rosenthal When we talk about aging, we’re really not looking at many of the positive sides. Many of us come into the heights of our careers and knowledge only in our forties, fifties, even sixties. The whole point of living is to live and to make a contribution, not to live your life in fear of aging. Life-cycle research has demonstrated that people actually aren’t happiest in their twenties.
Blackman The concept of antiaging is anathema to those who study the aging process, gerontologists or geriatricians. The whole philosophy implies that aging is inherently something to be prevented and avoided rather than understood—rather than learning to live one’s life with grace in each epoch of life. Our country is unusual in that it no longer venerates the wisdom and experience of aging.