Did Viruses Make Us Human?

By Kathy A. Svitil|Friday, November 01, 2002
Around 6 million years ago, some unknown genetic changes caused chimpanzees and humans to diverge from a common ancestor and set off along very different evolutionary paths. John McDonald, a molecular evolutionist at the University of Georgia, attributes this split to a most unlikely trigger—bits of "junk" DNA that we probably inherited from ancient viruses.

The human genome is littered with scraps of DNA that serve no clearly defined function. Scientists believe these transposons—so called because they can jump around the chromosomes—were acquired millions or billions of years ago, when viruses inserted their own DNA into that of the host. Until recently, transposons were regarded as genetic junk. But when geneticists discovered that the junk accounts for nearly half of our genome, "people started to seriously consider that they might contribute to evolution," McDonald says.

McDonald and King Jordan from the National Institutes of Health in Bethesda, Maryland, have now bolstered that view. They looked at one family of 147 related transposons, called HERV-K elements, and compared them in several different primate species. A single HERV-K element is present in humans but not in chimps. Judging from other measures of genetic change, this transposon appeared 6 million years ago, exactly when humans and chimps went their separate ways. McDonald hypothesizes that bits of viral DNA might have inserted themselves and altered functional genes, modifying the proteins they make, or the viral bits might have incited a reshuffling of the primate genome. "We like to think that our DNA must be serving us, but the vast majority of our genome is not directly related to our own function. We are carrying sequences that serve only the DNA. We're just part of a larger picture," McDonald says.

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